Breaking Through the Bottlenecks in High-Potent Drug Production: The Safe and Compliant Path of Tofflon's Contained Tablet Press

High-Potent drugs have emerged as a core growth driver in the pharmaceutical industry. Ranging from anti-cancer targeted drugs to orphan disease-specific therapeutics, these medications exert significant pharmacological effects at extremely low doses. However, their inherent high toxicity poses rigorous challenges to the production process. Risks such as dust leakage, occupational exposure for operators, cross-contamination hazards, and international regulatory barriers not only restrict pharmaceutical companies' capacity expansion but also may delay product launches due to compliance issues, causing them to miss market opportunities.

With three decades of deep expertise in pharmaceutical equipment, Tofflon has developed a containment tablet press integrating "ultimate containment, intelligent control, and end-to-end compliance" to address the core pain points of high-potent drugs production. This not only builds a health barrier for operators while enabling pharmaceutical companies to easily overcome compliance hurdles, achieving dual breakthroughs in safety and efficiency in the high-potent drugs sector.

Core Technologies: Building a Comprehensive Containment Protection System

The safety of HPAPI production lies at its core in "isolation"—isolating materials from operators, materials from the environment, and cross-contamination between different batches. Tofflon's contained tablet press system establishes a full-chain protection system from compression area design and process connection to intelligent monitoring, turning "zero-leakage production" from a concept into reality.

Figure 1：T20WIP Tablet Press

The negative pressure isolator of tablet press serves as the cornerstone of the entire protection system. Equipped with a stable negative pressure system of -100Pa±20Pa and paired with H14-grade high-efficiency filters, it achieves a 99.995% dust collection rate. The isolator features a fully welded stainless steel structure combined with inflatable sealing technology, completely eliminating leakage through gaps.

End-to-end contained connection further eliminates exposure risks during material transfer. In traditional production, materials pass through multiple interfaces from feeding and tableting to dedusting and metal detecting, with each transfer potentially becoming a leakage hazard. Tofflon adopts an "IBC + αβ valve" combination for feeding, enabling materials to be transported from the IBC to the tableting chamber without any exposure. It also adopts an integrated design of the deduster and metal detector, reducing transfer points for tablets after compression.