Alternating Tangential Flow Perfusion System

ATF tangential flow, also known as alternating tangential flow, connects hollow fiber column, high pressure air pump and diaphragm vacuum pump to adjust the pressure difference between air pump and vacuum pump, so that cells and culture medium through the hollow fiber column repeatedly alternate, so as to achieve cell interception in the hollow fiber column culture method. The tangential flow technique of ATF can effectively reduce the shear force of cells, so that cells can obtain a higher number of cell density and product yield in a short time at a higher perfusion rate. It is suitable for irrigation culture and continuous culture and other scale-up production technology. ATF alternating tangential flow system is an efficient external interception device, through the use of different aperture consumables can effectively interception cells, proteins and other convenient use with stainless steel fermenter, disposable reactor, disposable shaker and other equipment, greatly improve productivity, shorten the production cycle, improve production efficiency.