AAV Solution

Adeno-associated virus（AAV）belongs to parvovirus family with low pathogenicity. Adeno-associated virus vector is a gene delivery tool based on AAV genome. It has the advantages of low immunogenicity and site-specific integration ability, and is considered to have good safety. It shows great therapeutic prospects in the treatment of hereditary retinal diseases, spinal muscular atrophy, AADC deficiency and hemophilia, and is considered to be the most promising gene therapy vector. The production steps of AAV mainly include cell culture, virus infection, replication and large-scale culture, virus collection and purification, quality inspection and drug packaging. Tofflon can provide solutions from laboratory to mass production, including adhesion and suspension systems, and develop AAV affinity fillers with advantages, which have successfully assisted R&D and production of many related enterprises, and can provide key support from R&D to commercial implementation.

Tofflon Science and Technology Group Co., Ltd.

Purification Process
Cryopreservation Of The Original Solution
Auxiliary System
Preparation
Isolation System
Isolation System1
Isolation System2

Centrifugal

Membrane Filtration

Chromatographic Process

Parts

(M+E+C)&AI&

Relying on the understanding of regulations and processes, provide reliable end-to-end equipment and facilities from R&D to commercialization; Through planning and design, procurement management, engineering construction, system verification and other processes, integrated delivery of factories with specific functions; Provide core process consumables such as culture medium, filler, filter and disposable reaction bag to assist process optimization and solve the problem of stock solution production; Relying on information and intelligent time experience, we will provide forward-looking and professional digital planning to help enterprises transform digitally.